Associate Research Scientist/Scientist - Biology

• Ph.D with Postodoctoral or Masters with 5+ years of hands-on experience in cell-based assay development and troubleshooting skills; ability to handle different plate formats for small molecule screening 

• Reporting to senior team leader, work with a group of in vitro assay biologists, learning and coaching group members to improve skills and productivity 

• Independently design, conduct, optimize and proactively troubleshoot assays 

• Develop, optimize and validate biochemical and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules 

• Work on the bench implementing state-of-the-art technologies for the different assay platforms 

• Ensure robust and high-quality assays with efficient use of automation and instrumentation 

• Data processing, interpretation and presentation to cross functional team members 

• Proposing, planning, quoting, tracking reagent needs, usage and executing timelines for each study 

• Work closely with other biology groups involved in screening, cell biology, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Requirements

• Extensive work experience in cell biology and biochemistry techniques 

• Good working knowledge of transcription-based studies, targeted protein degradation, target identification and validation 

• Cell culture experience and in handling different immortalized cell lines, primary cultures, 3D cultures 

• Ability to perform transient transfections and generate stable cell lines  

• Good working knowledge of immunoprecipitation and Western blotting for protein analysis, quantification and in studying protein-protein interactions 

• Experience in fluorescence microscopy and high-content imagining is an advantage  

• Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an advantage 

• Experience in CRISPR-CAS9 knock-out and siRNA/shRNA knock-down studies  

• Experience with site-directed mutagenesis is beneficial but not a must  

• Candidates must be capable of excellent teamwork in a fast-paced, multidisciplinary environment, where meeting timelines will be essential. 

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•  Excellent data analysis and interpretation skills

• An ability to overcome technical challenges and exercise sound judgment under pressure  

• High self-motivation to initiate projects and work independently under aggressive deadlines 

• A strong technical knowledge with exceptional attention to detail 

• An excellent personal rapport and an ability to engender trust and respect 

• An ability to work well as part of a small focussed team and build relationships 

• An exceptional communication skill and an ease in interaction with all stakeholders

• An infectious enthusiasm for life, work and making a difference to the world in which we live 

• A bright, friendly, flexible personality with agility to switch between different skill sets 

• An exceptional organisational skill that thrives working in a fast-paced and vibrant team environment 

• Positivity, focus and a winning mentality allied with kindness 

• Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture