An AI agent that applies to roles like this on employers' own sites. 25 applications free, no card needed.
Posted over 15 days ago, so the role may have closed. Confirm on the employer's page when you apply, or see similar jobs.
Job Description
- :
- • We are seeking a highly skilled and motivated Structural Biologist to join our drug
- discovery programs. The ideal candidate will bring deep expertise in
- macromolecular structure determination and modeling, with a focus on elucidating
- protein structures, analyzing ligand binding, and driving rational drug design in
- collaboration with computational and medicinal chemistry teams.
- Key Responsibilities:
- • Analyze protein-ligand interactions to inform medicinal chemistry and lead
- optimization efforts.
- • Conduct molecular dynamics (MD) simulations and free energy calculations to
- evaluate complex stability and binding energetics.
- Apply structural insights to guide hit-to-lead and lead optimization strategies.
- (Preferred) Utilize machine learning models to support binding site prediction or
- compound prioritization.
- Required Skills & Experience:
- • Strong expertise in structural biology techniques, such as crystallography, cryo-
- EM, or NMR are desirable.
- • Proficient in macromolecular modeling and structure refinement tools (e.g.,
- Phenix, Coot, Chimera, PyMOL).
- • Experience with protein-ligand docking, structure validation, and interaction
- mapping.
- • Hands-on experience with molecular dynamics simulations using tools such as
- GROMACS, AMBER, NAMD, or CHARMM.
- • Familiarity with structure-based drug design platforms (e.g., Schrödinger,
- AutoDock).
- • Scripting or programming experience (Python, R, Bash) for workflow automation and
- structural data analysis.
- Preferred Qualifications:
- Ph.D. in Structural Biology, Biophysics, Computational Biology or related field.
- Demonstrated experience in drug discovery pipelines, especially in target
- validation and lead optimization.
- • (Preferred) Background in machine learning or AI applied to biomolecular structure
- or ligand interaction prediction.
- • Strong publication record or demonstrated project impact in therapeutic
- development.
- What We Offer:
- Work on high-impact, discovery-stage therapeutic programs.
- Collaborative and interdisciplinary research environment.
- Access to state-of-the-art computational and structural biology platforms.
Skills
PythonData AnalysisMachine LearningAiWorkflow AutomationIf a job posting appears fraudulent, asks for payment, contains misleading information, or violates our guidelines, please report it immediately. Our team will review it promptly, Jobaaj does not charge any fee from the applicants.
About Company
Meril’s core objective is to design, manufacture and distribute clinically relevant, state-of-the-art and best-in-class medical devices to alleviate human suffering and improve quality of life. We thus have a strong commitment towards R & D and adherence to best quality standards in Manufacturing, Scientific Communication and Distribution known today. Origin Established in 2006, Meril was launched in line with the health-care diversification plan by a large format Indian multi-national company. Disclaimer: Information on Meril Digital / Social Media platform is not intended to be a substitute for professional medical advice, diagnosis or treatment. Meril does not recommend self-management of health issues.
Similar Jobs
View all
New Data Science Analytics & Machine Learning roles in Vapi.
One email a day. Unsubscribe any time.
