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Job Description
Principal Scientist:
- Lead and manage a multidisciplinary scientific team of 12-15 FTEs ensuring high-quality project delivery.
- Handle client communications and independently manage technical calls with global stakeholders.
- Oversee project planning, execution, timelines, and resource allocation.
- Provide scientific guidance, troubleshooting, and mentoring to team members.
- Ensure compliance with quality, safety, and organizational standards.
- Collaborate cross-functionally to support business and operational goals.
- Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance
- Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography
- Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations
- Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately
- Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM
- Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS
- Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities
- Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation
- Experience in process R&D, scale-up synthesis, and purification from gm to kg scale
- Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities
- Proficient in 1H NMR, HPLC, and LCMS interpretation
- Strong project execution and team collaboration skills
- Synthesis and purification of complex antibody drug conjugate (ADC) molecules
- Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs
- Synthesis of highly potent drug molecules – payloads
- Purification of complex and large molecules by flash column and HPLC
- Handling various type chemistry with different payloads
- Interpretation and characterisation of higher molecular weight compounds
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- PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.
- Strong experience in CRO/CDMO research environment.
- Proven team management experience with exposure to handling multiple projects.
- Excellent communication and client-facing skills.
- Ability to drive productivity, scientific excellence, and team development.
- Masters in Organic Chemistry with 1-3 years of experience in the CRO Industry Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.
- Proactive, highly motivated with a can do attitude
- Exceptional interpersonal skills.
- Masters in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry
- Adherence to safe practices and procedures
- Contribution to the development of safety protocols and systems
- Must be able to prioritize and organize work responsibilities in order to meet deadlines
Skills
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About Company
o2h group is a cluster of companies focused on delivering integrated drug discovery services and investments to biotech companies and researchers globally. The group has deep expertise in chemistry, biology, and AI/ML, with state-of-the-art research facilities in India and the UK. o2h group also invests in early-stage biotech companies through its venture capital arm, o2h ventures.
Important dates & deadlines?
Application Deadline
14 Sep 26, 02:51 PM IST
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